Designs for Health SAMe

by Designs for Health

Designs for Health SAMe is a naturally occurring metabolite found in the human body as well as in plant and animal foods. It is the most active of all methyl donors and has been compared to ATP in its importance for the body.

SAMe is naturally synthesized in humans from the amino acid methionine in the presence of the cofactors B12 and folate.

SAMe is involved in the synthesis of neurotransmitters, the hormone melatonin, phospholipids, and polyamines, which control cellular growth.

It is also the source of methyl groups inside the nucleus for DNA methylation, which controls gene expression and masking of genetic damage.

These capsules provide 200 mg of SAMe along with vitamins B6, B12, and folate as 5-MTHF in order to provide cofactors for the natural conversions of SAMe to L-homocysteine and then safely to L-cysteine.


Serving Size 1 capsule

Amount Per Serving .....% Daily Value

Vitamin B-6 ... 5 mg 250%
(as Pyridoxal-5-Phosphate)

Folate ... 100 mcg 25%
(as Quatrefolic' [65]-5-Methyltetrahydrofolate, glucosamine salt 200 mcg)

Vitamin B-12 (as Methylcobalamin) ... 50 mcg 830%

SAMe ... 200 mg *
(as S-Adenosyl-L-Methionine Disulfate P-Toluenesulfate)

*Daily Value not established.

Other Ingredients:

Microcrystalline cellulose, vegetable stearate, calcium chloride anhydrous, calcium oxide.

*These statements have not been evaluated by the U.S. Food and Drug Administration. This product is not intended to treat, mitigate, diagnose or cure any disease. 

Customer Reviews

Based on 1 review
Quality SAMe

It was such a relief to find a quality brand of SAMe for a fair price. I’ve been taking this for a few years now and can’t say enough about about it as a supplement. This is my favorite brand since it includes B vitamins which are essential for overall health as well. My shipment arrived much quicker than I expected too. I’ll definitely be ordering again!

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