Thorne Research Methyl-Guard Plus

by Thorne Research

Thorne Research Methyl-Guard Plus provides support for heart, blood vessel, brain, nerve, and bone health.

Contains higher amounts of 5-MTHF (active folate), B6, B12.

Riboflavin 5'-phosphate added for extra homocysteine metabolism support.

Easy 3 capsules daily dosing*

Methylation – the addition of a methyl group (CH3 – one carbon attached to three hydrogens) to another molecule – is an essential and vital biochemical process within the human body that is involved in a large number of biochemical pathways involving neurotransmitters, detoxification, cardiovascular health, eye health, muscle health, bone health, and redox balance. A number of specific nutrients are necessary for methylation to occur normally.

Methyl-Guard Plus contains higher amounts of 5-MTHF (the active form of folate), pyridoxal 5'-phosphate (active B6), and methylcobalamin (active B12), than our original Methyl-Guard. We have also added riboflavin 5'-phosphate (the active form of vitamin B2) for its positive effect on homocysteine metabolism and methylation.* These ingredients provide the necessary nutrients the body uses to push forward the process of methylation. Methyl-Guard Plus is more concentrated, so your patients will appreciate the recommended daily amount of three capsules, which will improve compliance. Our original Methyl-Guard is still available.

Suggested Use: Take 1-3 capsules daily or as recommended by your health practioner. 


Serving Size: Three Capsules

Three Capsules Contain......%DV

Riboflavin (as Riboflavin 5'-Phosphate Sodium) ......90 mg......  6,923%

Vitamin B6 (as Pyridoxal 5'-Phosphate) .....45 mg ...... 2,647%

Folate (3 mg as L-5-Methyltetrahydrofolatet from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt)...... 5 mg DFE...... 1,250%

Vitamin B12 (as Methylcobalamin) ......3 mg..... 125,000%

Betaine Anhydrous (Trimethylglycine)...... 1.8 g

*Daily Value (DV) not established.

Other Ingredients:

Hypromellose (derived from cellulose) capsule, Calcium Citrate, Calcium Laurate.


This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.

If pregnant, consult your health professional before using this product.

5-methyl-tetrahydrofolate (5-MTHF) supplementation is not recommended concurrently with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic activity; however, 5-MTHF has not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.

* These statements have not been evaluated by the U.S. Food and Drug Administration. This product is not intended to treat, mitigate, diagnose or cure any disease.


Customer Reviews

Based on 3 reviews
Sharon Ligon

Thorne Research Methyl-Guard Plus

Donna Austin
Methyl-Guard Plus

I have been pleased with my products

MG Excellent Plus

All steps from ordering thru receipt are easy and reliable. I can't take folic acid, so as my doctor instructed, I take this form of folate. IT WORKS!

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